:: Volume 26, Issue 4 (2020) ::
Sci J Forensic Med 2020, 26(4): 247-251 Back to browse issues page
Suicide Following Injection of Imidacloprid: a Case Report
N. Asadinejad *1, M. Rahimi2
1- Forensic Medicine Organization of Mazandaran Province, Sari, Iran , drasadinejadforensic@gmail.com
2- Department of Clinical Toxicology and Poisoning, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:   (904 Views)
Aims: Imidacloprid is a neonicotinoid insecticide that does not block nicotinic acetylcholine receptors in the sense of an antagonist but acts as a stimulant and agonist for this receptor. In this study, a case of suicide with injectable imidacloprid was reported.
Patient & Methods: At the scene of the death of a 24-year-old woman, she was lying on the ground in front of the first step of the house. His death was confirmed by the emergency services, and a syringe impregnated with poison and several cans of agricultural poison were discovered and handed over to the city's intelligence agents.
Findings: In the physical examination and legal autopsy, the corpse bruise was naturally colored in the trunk's posterior areas, and the corpse was frozen. Cyanosis of the lips, nails, and subcutaneous injection site was evident outside the right umbilicus and behind the left hand. Necropsy findings of pulmonary edema and brief fluid in both pleural spaces showed a total of about 20 ml. Vitreous fluid, blood, bile, liver, kidney, stomach contents, and tissue of the injection site were sampled for toxicological tests.
Conclusion: Many cases of acute imidacloprid poisoning occur with mild symptoms, the most common of which are gastrointestinal and neurological manifestations, and the mortality rate is low. If you take too much of this toxin, the initial symptoms will appear as cardiovascular and central nervous system effects, eventually leading to death. Careful monitoring of acute patients exposed to imidacloprid toxin who present with these symptoms is essential.
Keywords: Suicide|Poisoning|Imidacloprid ,
Full-Text [PDF 437 kb]   (93 Downloads)    
Article Type: Case Report | Subject: Forensic Toxicology
* Corresponding Author Address: Legal Medicine Organization, Darya 19 Street, Noor Street, Mahmood Abad, Iran. Postal code: 4631893771
1. Prosser JM, Perrone J, Pines JM. The epidemiology of intentional non-fatal self-harm poisoning in the United States:2001-2004. J Med Toxicol. 2007;3(1):20-4. [Link] [DOI:10.1007/BF03161034] [PMID] [PMCID]
2. Jaschke P, Nauen R, Schindler M, Elbert A. Overview of the status and global strategy for neonicotinoids. J Agric Food Chem. 2011;59(7):2897-908. [Link] [DOI:10.1021/jf101303g] [PMID]
3. Van der Sluijs J, Simon-Delso N, Goulson D, Maxim L, Bonmatin J, Belzunces L. Neonicotinoids, bee disorders and the sustainability of pollinator services. Curr Opin Environ Sustain. 2013;5(3-4):293-305. [Link] [DOI:10.1016/j.cosust.2013.05.007]
4. Thompson DA, Lehmler HJ, Kolpin DW, Hladik ML, Vargo JD, Schilling KE, et al. A critical review on the potential impacts of neonicotinoid insecticide use: Current knowledge of environmental fate, toxicity, and implications for human health. Environ Sci Process Impact. 2020;22(6):1315-46. [Link] [DOI:10.1039/C9EM00586B] [PMID]
5. Tomizawa M, Casida JE. Neonicotinoid insecticide toxicology: Mechanisms of selective action. Annu Rev Pharmacol Toxicol. 2005;45(1):247-68. [Link] [DOI:10.1146/annurev.pharmtox.45.120403.095930] [PMID]
6. Tomizawa M, Casida JE. Selective toxicity of neonicotinoids attributable to specificity of insect and mammalian nicotinic receptors. Annu Rev Entomol. 2003;48:339-64. [Link] [DOI:10.1146/annurev.ento.48.091801.112731] [PMID]
7. Wu IW, Lin JL, Cheng ET. Acute poisoning with the neonicotinoid insecticide imidacloprid in N-methyl pyrrolidone. J Toxicol Clin Toxicol. 2001;39(6):617-21. [Link] [DOI:10.1081/CLT-100108494] [PMID]
8. Phua DH, Lin CC, Wu ML, Deng J. Neonicotinoid insecticides: An emerging cause of acute pesticide poisoning. Clin Toxicol. 2009;47(4):336-41. [Link] [DOI:10.1080/15563650802644533] [PMID]
9. Mohamed F, Gawarammana I, Robertson TA, Roberts MS, Palangasinghe C, Zawahir S, et al. Acute human self-poisoning with imidacloprid compound: A neonicotinoid insecticide. PLoS One. 2009;4(4):e5127. [Link] [DOI:10.1371/journal.pone.0005127] [PMID] [PMCID]
10. Adams RD, Perry L, Bennett A, Thompson J, Vale J, Eddleston M, et al. The NPIS pesticide surveillance project neonicotinoids: Comparison of toxicity against other insecticide classes. Clin Toxicol. 2013;51(4):353. [Link]
11. Forrester MB. Neonicotinoid insecticide exposures reported to six poison centers in Texas. Hum Exp Toxicol. 2014;33(6):568-73. [Link] [DOI:10.1177/0960327114522500] [PMID]
12. David D, George IA, Peter JV. Toxicology of the newer neonicotinoid insecticides: Imidacloprid poisoning in a human. Clin Toxicol. 2007;45(5):485-6. [Link] [DOI:10.1080/15563650701338229] [PMID]
13. Panigrahi AK, Subrahmanyam DK, Mukku KK. Imidacloprid poisoning: A case report. Am J Emerg Med. 2009;27(2):256.e5-6. [Link] [DOI:10.1016/j.ajem.2008.06.035] [PMID]
14. Iyyadurai R, George IA, Peter JV. Imidacloprid poisoning-newer insecticide and fatal toxicity. J Med Toxicol. 2010;6(1):77-8. [Link] [DOI:10.1007/s13181-010-0041-6] [PMID] [PMCID]
15. Kumar A, Verma A, Kumar A. Accidental human poisoning with a neonicotinoid insecticide, imidacloprid: A rare case report from rural India with a brief review of literature. Egypt J Forensic Sci. 2013;3(4):123-6. [Link] [DOI:10.1016/j.ejfs.2013.05.002]
16. Hung YM, Meier KH. Acute® Confidor (imidacloprid-N-methyl pyrrolidone) insecticides intoxication with mimicking cholinergic syndrome. Toxicol Ind Health. 2005;21:137-40. [Link] [DOI:10.1191/0748233705th217oa]
17. Hung YM, Lin SL, Chou KJ. Imidacloprid-N-methyl pyrrolidone insecticides poisoning mimicking cholinergic syndrome. Clin Toxicol. 2006;44(5):771-2. [Link]
18. Huang NC, Lin SL, Chou CH, Hung Y, Chung H, Huang S. Fatal ventricular fibrillation in a patient with acute imidacloprid poisoning. Am J Emerg Med. 2006;24(7):883-5. [Link] [DOI:10.1016/j.ajem.2006.03.008] [PMID]
19. Nistor N, Frăsinariu OE, Ştreangă V. Acute poisoning with neonicotinoid insecticide. In: Malangu N, editor. Poisoning- From specific toxic agents to novel rapid and simplified techniques for analysis. Unknown city: IntechOpen; 2017. [Link] [DOI:10.5772/intechopen.72004]
20. Shadnia S, Moghaddam HH. Fatal intoxication with imidacloprid insecticide. Am J Emerg Med. 2008;26(5):634.e1-4. [Link] [DOI:10.1016/j.ajem.2007.09.024] [PMID]
21. Karatas AD. Severe central nervous system depression in a patient with acute imidacloprid poisoning. Am J Emerg Med. 2009;27(9):1171.e5-7. [Link] [DOI:10.1016/j.ajem.2009.01.006] [PMID]
22. Agha A, Bella A, Aldosary B, Kazzi Z, Alhumaidi M. Imidacloprid poisoning presenting as leukoclastic vasculitis with renal and hepatic dysfunction. Saudi J Kidney Dis Transpl. 2012;23(6):1300-3. [Link]
23. Fuke C, Nagai T, Ninomiya K, Fukasawa M, Ihama Y, Miyazaki T. Detection of imidacloprid in biological fluids in a case of fatal insecticide intoxication. Leg Med. 2014;16(1):40-3. [Link] [DOI:10.1016/j.legalmed.2013.10.007] [PMID]
24. Proenca P, Teixeira H, Castanheira F, Pinheiro J, Monsanto PV, Marques EP, et al. Two fatal intoxication cases with imidacloprid: LC/MS analysis. Forensic Sci Int. 2005;153(1):75-80. [Link] [DOI:10.1016/j.forsciint.2005.04.015] [PMID]
25. Liu H, Kan B, Jian X, Zhang W, Zhou Q, Wang J. Parasuicidal poisoning by intramuscular injection of insecticide: A case report. Exp Ther Med. 2013;6(3):696-8. [Link] [DOI:10.3892/etm.2013.1216] [PMID] [PMCID]

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