Background: The purpose of this study is description, diagnosis and necessity of psychotherapy and assessment of comorbidity disorders for patients with transsexual.

 Methods: Two cases had referred to clinic of psychology for the demandant of sexuality change. This two case were evaluated through clinical interview, a personality questionnaire of NEO (NEO-FFI) and the Minnesota Multifaceted personality inventory-short form (MMPI).

 Results: Overall results showed the applicants who refer to psychological clinics in order to change the gender, should be examined by diagnostic tools and clinical interviews by regard to clinical judgment permission of transsexuals grant to them. As in case1, are observed borderline and hystrionic personality characteristics (not pure),  lack of assertiveness and depression. 

 Conclusion: According to our results, two clients have demands for changing of their gender However, They experience various psychological conditions, Thus it must be done psychotherapy before therapy through surgery.