Background: Using stimulant substances is one of the main issues of public health in the recent decade. In such situation using opiates is changing to using stimulant substances. The present survey aims at comparing the rate of self esteem, self- efficacy and self- regulation in opiates and stimulant substance dependents with normal people.

Methods: This research is a observational, cross- sectional and cooperative research .The sampling in the study group is 108 person (70 person dependent to opiates and 38 person dependent to stimulant substances).They have been selected in availability method and  the comparing group which includes 106 normal person has been selected randomly.

Findings: Among self- esteem and self- efficacy, self- esteem and self- regulation, and finally self- efficacy and self- regulation, exist a positive and meaningful correlation. They are respectively as follows: (r=/048,P<0/01), (r=/055,P<0/01) and (r=/055,P<0/01).The opiate dependent people, the stimulant dependent people, and normal people are different significantly and meaningfully in the rates of self- esteem, self- efficacy and self- regulation. The rates of self- esteem in the opiate and stimulants dependent people is meaningfully lower than normal people but between two groups who are dependent to opiates and stimulant substances there is not a meaningful difference. Also considering the self- efficacy variable, there is a meaningful difference, between the opiate dependent people and the stimulant dependent people, and between the opiate dependent people and normal people. But no meaningful difference has been observed between stimulant dependent people and normal people. The results show that stimulant dependent people and normal people have lower self- efficacy rate. Consequently self- esteem, self- efficacy and self- regulation is preventive and protective factor against dangerous behaviors such as drug abusing.

Conclusion: Since the different factors have rule in beginning of abusing drugs, therefore, the comparison of three derivatives of self (self- esteem, self- efficacy and self- regulation) is very significant in detecting fundamental factors responsible in prevention and treatment.