|
Method and Risk of Screening for Fetal Chromosomal Abnormalities in Mothers Referred to Ahvaz Legal Forensic Medicine
|
Najimeh Saadati1    , Seyed Sajad Marashi1 , Mojgan Barati1 , Samira Negahdari2 , Elham Modheji3 |
1- Infertility and Perinatology Research Center, Department of Obstetrics and Gynecology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2- Legal Medicine Research Center, Iranian Legal Medicine Organization, Tehran, Iran , s.negahdari2018@gmail.com
3- Legal Medicine Research Center, Iranian Legal Medicine Organization, Tehran, Iran |
|
|
Abstract: (22 Views) |
Introduction: Prenatal screening for chromosomal abnormalities, utilizing maternal serum markers, maternal age, and ultrasound, is standard practice for pregnant women in Iran and many other countries between 11 and 13 weeks of gestation. This study aimed to examine the screening methods and risks associated with fetal chromosomal abnormalities in pregnant women who received medical abortion permits by the Forensic Medicine Centers of Khuzestan over a five-year period.
Methods: This analytical cross-sectional study included 3,905 cases referred for medical abortion licenses due to fetal complications between 2016 and 2020 at the Forensic Medicine Centers in Ahvaz, Khuzestan, Iran. Of these, 637 cases (16.31%) involving fetal chromosomal abnormalities were analyzed. Data were processed using SPSS (version 22), with statistical significance defined as a P-value of less than 0.05.
Results: The mean age of the mothers in the study group was 35.46 ± 6.06 years. There was no statistically significant relationship between maternal age and the incidence of fetal trisomies 13, 18, or 21 (P>0.05). Of the samples analyzed, 73.3% were identified with trisomy 21, 18% with trisomy 18, and 4.7% with trisomy 13. Furthermore, no significant association was observed between maternal age and nuchal translucency (NT) measurements in mothers either under or over 35 years of age (P>0.05).
Conclusion Screening tests are an effective method of screening women at risk of giving birth to fetuses with chromosomal abnormalities, and further research is recommended to determine the accuracy of these tests in the larger Iranian community. The NIPT was found as a method with high accuracy and significantly reduces the need for invasive routine screening procedures in different risk groups of pregnant women. |
|
| Keywords: Legal abortion, Chromosome Abnormalities, Prenatal diagnosis, Karyotype, Trisomy |
|
|
|
Type of Article: Research Article |
Subject:
Identification
Received: 2026/02/24 | Revised: 2026/06/28 | Accepted: 2026/06/28
|
|
|
|
|
|
|
| Send email to the article author |
|
|
