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Evaluation of the Utility of Research Autopsy in Oncology
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Mohammad Zarenezhad1    , Alireza Doroudchi2 , Abdorrasoul Malekpour2 , Homayoun Hosseininezhad2 , Reza Khoshnood2 , Maryam Valiei2 |
1- Legal Medicine Researh Center, Iranian Legal Medicine Organization, Tehran, Iran , fleglaresearch@gmail.com
2- Legal Medicine Researh Center, Iranian Legal Medicine Organization, Tehran, Iran |
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Abstract: (1592 Views) |
An autopsy is a post-mortem medical procedure performed on a deceased person with the primary purpose of collecting tissue to support basic research and knowledge translation. This method is increasingly used to investigate the pathophysiological mechanisms of cancer development, metastasis, and treatment resistance. In this review article, we discuss the reason for using research autopsy in cancer research and provide evidence-based discussion of the quality of postmortem tissues compared to other types of biological samples. It also discusses the advantages of using postmortem tissues over other types of biological samples, including the large amount of tissue available and the multi-area sampling that is available, which is not possible in living patients. An autopsy helps identify the clonal origin and ways in which metastases spread. Also, the study of the effect of treatments on the tumor and the creation of rare and tumor-derived tissue banks in the patient is an integral part of forensic strategies and research autopsy. |
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| Keywords: Forensic medicine, Cancer, Research autopsy |
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Full-Text [PDF 412 kb]
(1345 Downloads)
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Type of Article: Review Article |
Subject:
Identification
Received: 2022/08/11 | Revised: 2023/02/22 | Accepted: 2022/11/21 | ePublished: 2023/02/5
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