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:: Volume 26, Issue 3 (2020) ::
Iran J Forensic Med 2020, 26(3): 199-209 Back to browse issues page
Biomarkers, a Diagnostic Tool for Post-Traumatic Stress Disorder; Promising Horizons in Neuroscience Research
A. Eftekhari1 , M. Bakhtiari 2
1- Department of Clinical Psychology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Department of Clinical Psychology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran , Maryam_bakhtiyari@sbmu.ac.ir
Abstract:   (2506 Views)
Introduction: Post-traumatic stress disorder (PTSD) is a heterogeneous disorder that affects people at risk for trauma. Although its diagnostic features have been reclassified in the Diagnostic and Statistical Manual of Mental Disorders, Version 5 (DSM-5), the disorder is characterized by excessive and unwanted trauma reminders as well as the avoidance of trauma reminders. Cognitive patterns and negative moods of this heterogeneity indicate multiple neurological mechanisms in the context of PTSD. Research over the past few decades has shown several potential ways to identify diagnostic biomarkers for PTSD. These include monoadrenergic transmission systems, the hypothalamic-pituitary-adrenal axis (HPA), metabolic, hormonal pathways, inflammatory mechanisms, psychophysiological reactions, and cerebral neural circuits. The present study presents the research literature concerning the most promising biomarkers in diagnosing PTSD with special emphasis on the interaction between neurological effects on disease risk and progression of symptoms. Such biomarkers are likely to be identified by multidimensional models derived from comprehensive descriptions of molecular, neurological, behavioral, and clinical phenotypes.
Conclusion: Post-traumatic stress disorder biomarkers can provide promising horizons for early diagnosis and treatment of the disorder and provide clinicians with tools to make more accurate diagnoses of the disorder. Also, the existing research literature in this field can serve the biological contexts related to PTSD symptoms and future studies' goals.
Keywords: Neuroscience, Biomarkers, Diagnosis, Post-Traumatic Stress Disorder
Full-Text [PDF 458 kb]   (1188 Downloads)    
Type of Article: Editorial | Subject: Forensic Neurology
Received: 2020/11/22 | Revised: 2021/04/6 | Accepted: 2021/03/1 | ePublished: 2021/03/7
References
1. Dedert EA, Calhoun PS, Watkins LL, Sherwood A, Beckham JC. Posttraumatic stress disorder, cardiovascular, and metabolic disease: A review of the evidence. Ann Behav Med. 2010;39(1):61-78. [Link] [DOI:10.1007/s12160-010-9165-9] [PMID] [PMCID]
2. Kessler RC, Sonnega A, Bromet E, Hughes M, Nelson CB. Posttraumatic stress disorder in the national comorbidity survey. Arch Gen Psychiatry. 1995;52(12):1048-60. [Link] [DOI:10.1001/archpsyc.1995.03950240066012] [PMID]
3. Breslau N. The epidemiology of posttraumatic stress disorder: What is the extent of the problem. J Clin Psychiatry. 2001;62 Suppl 17:16-22. [Link]
4. Roberts AL, Galea S, Austin SB, Cerda M, Wright RJ, Rich-Edwards JW, et al. Posttraumatic stress disorder across two generations: Concordance and mechanisms in a population-based sample. Biol Psychiatry. 2012;72(6):505-11. [Link] [DOI:10.1016/j.biopsych.2012.03.020] [PMID] [PMCID]
5. Pitman RK, Rasmusson AM, Koenen KC, Shin LM, Orr SP, Gilbertson MW, et al. Biological studies of post-traumatic stress disorder. Nat Rev Neurosci. 2012;13(11):769-87. [Link] [DOI:10.1038/nrn3339] [PMID] [PMCID]
6. Galatzer-Levy IR, Bryant RA. 636,120 ways to have posttraumatic stress disorder. Perspect Psychol Sci. 2013;8(6):651-62. [Link] [DOI:10.1177/1745691613504115] [PMID]
7. Powers A, Dixon HD, Conneely K, Gluck R, Munoz A, Rochat C, et al. The differential effects of PTSD, MDD, and dissociation on CRP in trauma-exposed women. Compr Psychiatry. 2019;93:33-40. [Link] [DOI:10.1016/j.comppsych.2019.06.007] [PMID] [PMCID]
8. Nichter B, Norman S, Haller M, Pietrzak RH. Psychological burden of PTSD, depression, and their comorbidity in the U.S. veteran population: Suicidality, functioning, and service utilization. J Affect Disord. 2019;256:633-40. [Link] [DOI:10.1016/j.jad.2019.06.072] [PMID]
9. Nichter B, Norman S, Haller M, Pietrzak RH. Physical health burden of PTSD, depression, and their comorbidity in the US veteran population: Morbidity, functioning, and disability. J Psychosom Res. 2019;124:109744. [Link] [DOI:10.1016/j.jpsychores.2019.109744] [PMID]
10. Sheerin CM, Bountress KE, Meyers JL, Saenz De Viteri SS, Shen H, Maihofer AX, et al. Shared molecular genetic risk of alcohol dependence and posttraumatic stress disorder (PTSD). Psychol Addict Behav. 2020;34(5):613-9. [Link] [DOI:10.1037/adb0000568] [PMID]
11. Gidzgier P, Grundmann J, Lotzin A, Hiller P, Schneider B, Driessen M, et al. The dissociative subtype of PTSD in women with substance use disorders: Exploring symptom and exposure profiles. J Subst Abuse Treat. 2019;99:73-9. [Link] [DOI:10.1016/j.jsat.2019.01.004] [PMID]
12. Richards A, Kanady JC, Neylan TC. Sleep disturbance in PTSD and other anxiety-related disorders: An updated review of clinical features, physiological characteristics, and psychological and neurobiological mechanisms. Neuropsychopharmacology. 2020;45(1):240-1. [Link] [DOI:10.1038/s41386-019-0529-y] [PMID] [PMCID]
13. Combs E, Guston K, Kopak A, Raggio A, Hoffmann NG. Posttraumatic stress, panic disorder, violence, and recidivism among local jail detainees. Int J Prison Health. 2019;15(4):366-75. [Link] [DOI:10.1108/IJPH-06-2018-0036] [PMID]
14. Berenz EC, York TP, Bing-Canar H, Amstadter AB, Mezuk B, Gardner CO, et al. Time course of panic disorder and posttraumatic stress disorder onsets. Soc Psychiatry Psychiatr Epidemiol. 2019;54(5):639-47. [Link] [DOI:10.1007/s00127-018-1559-1] [PMID] [PMCID]
15. Stanley IH, Rogers ML, Hanson JE, Gutierrez PM, Joiner TE. PTSD symptom clusters and suicide attempts among high-risk military service members: A three-month prospective investigation. J Consult Clin Psychol. 2019;87(1):67-78. [Link] [DOI:10.1037/ccp0000350] [PMID]
16. Stanley IH, Hom MA, Boffa JW, Stage DRL, Joiner TE. PTSD from a suicide attempt: An empirical investigation among suicide attempt survivors. J Clin Psychol. 2019;75(10):1879-95. [Link] [DOI:10.1002/jclp.22833] [PMID] [PMCID]
17. Hoerster KD, Campbell S, Dolan M, Stappenbeck CA, Yard S, Simpson T, et al. PTSD is associated with poor health behavior and greater body mass index through depression, increasing cardiovascular disease and diabetes risk among U.S. veterans. Prev Med Rep. 2019;15:100930. [Link] [DOI:10.1016/j.pmedr.2019.100930] [PMID] [PMCID]
18. Scherrer JF, Salas J, Norman SB, Schnurr PP, Chard KM, Tuerk P, et al. Association between clinically meaningful posttraumatic stress disorder improvement and risk of type 2 diabetes. JAMA Psychiatry. 2019;76(11):1159-66. [Link] [DOI:10.1001/jamapsychiatry.2019.2096] [PMID] [PMCID]
19. Dyball D, Evans S, Boos CJ, Stevelink SAM, Fear NT. The association between PTSD and cardiovascular disease and its risk factors in male veterans of the Iraq/Afghanistan conflicts: A systematic review. Int Rev Psychiatry. 2019;31(1):34-48. [Link] [DOI:10.1080/09540261.2019.1580686] [PMID]
20. Cuthbert BN, Insel TR. Toward the future of psychiatric diagnosis: The seven pillars of RDoC. BMC Med. 2013;11:126. [Link] [DOI:10.1186/1741-7015-11-126] [PMID] [PMCID]
21. Zoladz PR, Diamond DM. Current status on behavioral and biological markers of PTSD: A search for clarity in a conflicting literature. Neurosci Biobehav Rev. 2013;37(5):860-95. [Link] [DOI:10.1016/j.neubiorev.2013.03.024] [PMID]
22. Schmidt U, Kaltwasser SF, Wotjak CT. Biomarkers in posttraumatic stress disorder: Overview and implications for future research. Dis Markers. 2013;35(1):43-54. [Link] [DOI:10.1155/2013/835876] [PMID] [PMCID]
23. Southwick SM, Bremner JD, Rasmusson A, Morgan CA, Arnsten A, Charney DS. Role of norepinephrine in the pathophysiology and treatment of posttraumatic stress disorder. Biol Psychiatry. 1999;46(9):1192-204. [Link] [DOI:10.1016/S0006-3223(99)00219-X]
24. Fonkoue IT, Marvar PJ, Norrholm S, Li Y, Kankam ML, Jones TN, et al. Symptom severity impacts sympathetic dysregulation and inflammation in post-traumatic stress disorder (PTSD). Brain Behav Immun. 2020;83:260-9. [Link] [DOI:10.1016/j.bbi.2019.10.021] [PMID] [PMCID]
25. Pan X, Kaminga AC, Wen SW, Liu A. Catecholamines in post-traumatic stress disorder: A systematic review and meta-analysis. Front Mol Neurosci. 2018;11:450. [Link] [DOI:10.3389/fnmol.2018.00450] [PMID] [PMCID]
26. Geracioti Jr TD, Baker DG, Ekhator NN, West SA, Hill KK, Bruce AB, et al. CSF norepinephrine concentrations in posttraumatic stress disorder. Am J Psychiatry. 2001;158(8):1227-30. [Link] [DOI:10.1176/appi.ajp.158.8.1227] [PMID]
27. Delahanty DL, Nugent NR, Christopher NC, Walsh M. Initial urinary epinephrine and cortisol levels predict acute PTSD symptoms in child trauma victims. Psychoneuroendocrinology. 2005;30(2):121-8. [Link] [DOI:10.1016/j.psyneuen.2004.06.004] [PMID]
28. Hawk LW, Dougall AL, Ursano RJ, Baum A. Urinary catecholamines and cortisol in recent-onset posttraumatic stress disorder after motor vehicle accidents. Psychosom Med. 2000;62(3):423-34. [Link] [DOI:10.1097/00006842-200005000-00016] [PMID]
29. Blanchard EB, Kolb LC, Prins A, Gates S, Mccoy GC. Changes in plasma norepinephrine to combat-related stimuli among Vietnam veterans with posttraumatic stress disorder. J Nerv Ment Dis. 1991;179(6):371-3. [Link] [DOI:10.1097/00005053-199106000-00012] [PMID]
30. Krystal JH, Abdallah CG, Pietrzak RH, Averill LA, Harpaz-Rotem I, Levy I, et al. Locus coeruleus hyperactivity in posttraumatic stress disorder: Answers and questions. Biol Psychiatry. 2018;83(3):197-9. [Link] [DOI:10.1016/j.biopsych.2017.09.027] [PMID]
31. McDougle CJ, Southwick SM, Charney DS, James RL. An open trial of fluoxetine in the treatment of posttraumatic stress disorder. J Clin Psychopharmacol. 1991;11(5):325-7. [Link]
32. Naegeli C, Zeffiro T, Piccirelli M, Jaillard A, Weilenmann A, Hassanpour K, et al. Locus coeruleus activity mediates hyperresponsiveness in posttraumatic stress disorder. Biol Psychiatry. 2018;83(3):254-62. [Link] [DOI:10.1016/j.biopsych.2017.08.021] [PMID]
33. Hendrickson RC, Raskind MA, Millard SP, Sikkema C, Terry GE, Pagulayan KF, et al. Evidence for altered brain reactivity to norepinephrine in veterans with a history of traumatic stress. Neurobiol Stress. 2018;8:103-11. [Link] [DOI:10.1016/j.ynstr.2018.03.001] [PMID] [PMCID]
34. Yang JJ, Jiang W. Immune biomarkers alterations in post-traumatic stress disorder: A systematic review and meta-analysis. J Affect Disord. 2020;268:39-46. [Link] [DOI:10.1016/j.jad.2020.02.044] [PMID]
35. Southwick SM, Krystal JH, Morgan CA, Johnson D, Nagy LM, Nicolaou A, et al. Abnormal noradrenergic function in posttraumatic stress disorder. Arch Gen Psychiatry. 1993;50(4):266-74. [Link] [DOI:10.1001/archpsyc.1993.01820160036003] [PMID]
36. Southwick SM, Krystal JH, Bremner JD, Morgan CA, Nicolaou AL, Nagy LM, et al. Noradrenergic and serotonergic function in posttraumatic stress disorder. Arch Gen Psychiatry. 1997;54(8):749-58. [Link] [DOI:10.1001/archpsyc.1997.01830200083012] [PMID]
37. Martin EI, Ressler KJ, Binder E, Nemeroff CB. The neurobiology of anxiety disorders: Brain imaging, genetics, and psychoneuroendocrinology. Psychiatr Clin North Am. 2009;32(3):549-75. [Link] [DOI:10.1016/j.psc.2009.05.004] [PMID] [PMCID]
38. Qiu ZK, Liu X, Chen Y, Wu RJ, Guan SF, Pan YY, et al. Translocator protein 18 kDa: A potential therapeutic biomarker for post-traumatic stress disorder. Metab Brain Dis. 2020;35(5):695-707. [Link] [DOI:10.1007/s11011-020-00548-9] [PMID]
39. Aslan EA. Up-to-date psychopharmacological treatments in post-traumatic stress disorder. Klinik Psikofarmakoloji Bulteni. 2018;28:332. [Link]
40. Frick A, Ahs F, Palmquist AM, Pissiota A, Wallenquist U, Fernandez M, et al. Overlapping expression of serotonin transporters and neurokinin-1 receptors in posttraumatic stress disorder: A multi-tracer PET study. Mol Psychiatry. 2016;21(10):1400-7. [Link] [DOI:10.1038/mp.2015.180] [PMID]
41. Sullivan GM, Ogden RT, Huang YY, Oquendo MA, Mann JJ, Parsey RV. Higher in vivo serotonin‐1a binding in posttraumatic stress disorder: A PET study with [11C] WAY‐100635. Depress Anxiety. 2013;30(3):197-206. [Link] [DOI:10.1002/da.22019] [PMID] [PMCID]
42. Parsey RV, Oquendo MA, Ogden RT, Olvet DM, Simpson N, Huang YY, et al. Altered serotonin 1A binding in major depression: A [Carbonyl-C-11] WAY100635 positron emission tomography study. Biol Psychiatry. 2006;59(2):106-13. [Link] [DOI:10.1016/j.biopsych.2005.06.016] [PMID]
43. Murrough JW, Huang Y, Hu J, Henry S, Williams W, Gallezot JD, et al. Reduced amygdala serotonin transporter binding in posttraumatic stress disorder. Biol Psychiatry. 2011;70(11):1033-8. [Link] [DOI:10.1016/j.biopsych.2011.07.003] [PMID] [PMCID]
44. Kang B, Xu H, McConnell ES. Neurocognitive and psychiatric comorbidities of posttraumatic stress disorder among older veterans: A systematic review. Int J Geriatr Psychiatry. 2019;34(4):522-38. [Link] [DOI:10.1002/gps.5055] [PMID]
45. Sagarwala R, Nasrallah HA. Changes in inflammatory biomarkers before and after SSRI therapy in PTSD: A review. Ann Clin Psychiatry. 2019;31(4):292-7. [Link]
46. Zoellner LA, Roy-Byrne PP, Mavissakalian M, Feeny NC. Doubly randomized preference trial of prolonged exposure versus sertraline for treatment of PTSD. Am J Psychiatry. 2019;176(4):287-96. [Link] [DOI:10.1176/appi.ajp.2018.17090995] [PMID]
47. Hamner MB, Hernandez-Tejada MA, Zuschlag ZD, Agbor-Tabi D, Huber M, Wang Z. Ziprasidone augmentation of SSRI antidepressants in posttraumatic stress disorder: A randomized, placebo-controlled pilot study of augmentation therapy. J Clin Psychopharmacolo. 2019;39(2):153-7. [Link] [DOI:10.1097/JCP.0000000000001000] [PMID]
48. Dunlop BW, Wong A. The hypothalamic-pituitary-adrenal axis in PTSD: Pathophysiology and treatment interventions. Prog Neuropsychopharmacol Biol Psychiatry. 2019;89:361-79. [Link] [DOI:10.1016/j.pnpbp.2018.10.010] [PMID]
49. Sheerin CM, Lind MJ, Bountress KE, Marraccini ME, Amstadter AB, Bacanu SA, et al. Meta‐analysis of associations between hypothalamic‐pituitary‐adrenal axis genes and risk of posttraumatic stress disorder. J Trauma Stress. 2020;33(5):688-98. [Link] [DOI:10.1002/jts.22484] [PMID]
50. Yehuda R. Neuroendocrine aspects of PTSD. Handb Exp Pharmacol. 2005;(169):371-403. [Link] [DOI:10.1007/3-540-28082-0_13] [PMID]
51. Walsh K, Nugent NR, Kotte A, Amstadter AB, Wang S, Guille C, et al. Cortisol at the emergency room rape visit as a predictor of PTSD and depression symptoms over time. Psychoneuroendocrinology. 2013;38(11):2520-8. [Link] [DOI:10.1016/j.psyneuen.2013.05.017] [PMID] [PMCID]
52. Mouthaan J, Sijbrandij M, Luitse JSK, Goslings JC, Gersons BPR, Olff M. The role of acute cortisol and DHEAS in predicting acute and chronic PTSD symptoms. Psychoneuroendocrinology. 2014;45:179-86. [Link] [DOI:10.1016/j.psyneuen.2014.04.001] [PMID]
53. Bremner JD, Vythilingam M, Vermetten E, Adil J, Khan S, Nazeer A, et al. Cortisol response to a cognitive stress challenge in posttraumatic stress disorder (PTSD) related to childhood abuse. Psychoneuroendocrinology. 2003;28(6):733-50. [Link] [DOI:10.1016/S0306-4530(02)00067-7]
54. Kolassa IT, Eckart C, Ruf M, Neuner F, De Quervain DJ, Elbert T. Lack of cortisol response in patients with posttraumatic stress disorder (PTSD) undergoing a diagnostic interview. BMC Psychiatry. 2007;7:54. [Link] [DOI:10.1186/1471-244X-7-54] [PMID] [PMCID]
55. Freidenberg BM, Gusmano R, Hickling EJ, Blanchard EB, Bremner JD, Frye C. Women with PTSD have lower basal salivary cortisol levels later in the day than do men with PTSD: A preliminary study. Physiol Behav. 2010;99(2):234-6. [Link] [DOI:10.1016/j.physbeh.2009.06.002] [PMID] [PMCID]
56. Galatzer-Levy IR, Steenkamp MM, Brown AD, Qian M, Inslicht S, Henn-Haase C, et al. Cortisol response to an experimental stress paradigm prospectively predicts long-term distress and resilience trajectories in response to active police service. J Psychiatr Res. 2014;56:36-42. [Link] [DOI:10.1016/j.jpsychires.2014.04.020] [PMID] [PMCID]
57. Yehuda R, Boisoneau D, Lowy MT, Giller EL. Dose-response changes in plasma cortisol and lymphocyte glucocorticoid receptors following dexamethasone administration in combat veterans with and without posttraumatic stress disorder. Arch Gen Psychiatry. 1995;52(7):583-93. [Link] [DOI:10.1001/archpsyc.1995.03950190065010] [PMID]
58. De Kloet CS, Vermetten E, Geuze E, Lentjes EGWM, Heijnen CJ, Stalla GK, et al. Elevated plasma corticotrophin-releasing hormone levels in veterans with posttraumatic stress disorder. Prog Brain Res. 2008;167:287-91. [Link] [DOI:10.1016/S0079-6123(07)67025-3]
59. Baker DG, Ekhator NN, Kasckow JW, Dashevsky B, Horn PS, Bednarik L, et al. Higher levels of basal serial CSF cortisol in combat veterans with posttraumatic stress disorder. Am J Psychiatry. 2005;162(5):992-4. [Link] [DOI:10.1176/appi.ajp.162.5.992] [PMID]
60. Matic G, Milutinovic DV, Nestorov J, Elakovic I, Jovanovic SM, Perisic T, et al. Lymphocyte glucocorticoid receptor expression level and hormone-binding properties differ between war trauma-exposed men with and without PTSD. Prog Neuropsychopharmacol Biol Psychiatry. 2013;43:238-45. [Link] [DOI:10.1016/j.pnpbp.2013.01.005] [PMID]
61. Yehuda R, Golier JA, Yang RK, Tischler L. Enhanced sensitivity to glucocorticoids in peripheral mononuclear leukocytes in posttraumatic stress disorder. Biol Psychiatry. 2004;55(11):1110-6. [Link] [DOI:10.1016/j.biopsych.2004.02.010] [PMID]
62. Yehuda R, Cai G, Golier JA, Sarapas C, Galea S, Ising M, et al. Gene expression patterns associated with posttraumatic stress disorder following exposure to the world trade center attacks. Biol Psychiatry. 2009;66(7):708-11. [Link] [DOI:10.1016/j.biopsych.2009.02.034] [PMID]
63. Van Zuiden M, Geuze E, Willemen HLDM, Vermetten E, Maas M, Amarouchi K, et al. Glucocorticoid receptor pathway components predict posttraumatic stress disorder symptom development: A prospective study. Biol Psychiatry. 2012;71(4):309-16. [Link] [DOI:10.1016/j.biopsych.2011.10.026] [PMID]
64. Bryant RA, Felmingham KL, Silove D, Creamer M, O'Donnell M, McFarlane AC. The association between menstrual cycle and traumatic memories. J Affect Disord. 2011;131(1-3):398-401. [Link] [DOI:10.1016/j.jad.2010.10.049] [PMID]
65. Glover EM, Mercer KB, Norrholm SD, Davis M, Duncan E, Bradley B, et al. Inhibition of fear is differentially associated with cycling estrogen levels in women. J Psychiatry Neurosci. 2013;38(5):341-8. [Link] [DOI:10.1503/jpn.120129] [PMID] [PMCID]
66. Michopoulos V, Rothbaum AO, Corwin E, Bradley B, Ressler KJ, Jovanovic T. Psychophysiology and posttraumatic stress disorder symptom profile in pregnant African-American women with trauma exposure. Arch Women Ment Health. 2015;18(4):639-48. [Link] [DOI:10.1007/s00737-014-0467-y] [PMID] [PMCID]
67. Rasmusson AM, Pinna G, Paliwal P, Weisman D, Gottschalk C, Charney D, et al. Decreased cerebrospinal fluid allopregnanolone levels in women with posttraumatic stress disorder. Biol Psychiatry. 2006;60(7):704-13. [Link] [DOI:10.1016/j.biopsych.2006.03.026] [PMID]
68. Mulchahey JJ, Ekhator NN, Zhang H, Kasckow JW, Baker DG, Geracioti Jr TD. Cerebrospinal fluid and plasma testosterone levels in post-traumatic stress disorder and tobacco dependence. Psychoneuroendocrinology. 2001;26(3):273-85. [Link] [DOI:10.1016/S0306-4530(00)00052-4]
69. Reijnen A, Geuze E, Vermetten E. The effect of deployment to a combat zone on testosterone levels and the association with the development of posttraumatic stress symptoms: A longitudinal prospective Dutch military cohort study. Psychoneuroendocrinology. 2015;51:525-33. [Link] [DOI:10.1016/j.psyneuen.2014.07.017] [PMID]
70. Karatzias T, Hyland P, Bradley A, Cloitre M, Roberts NP, Bisson JI, et al. Risk factors and comorbidity of ICD‐11 PTSD and complex PTSD: Findings from a trauma‐exposed population based sample of adults in the United Kingdom. Depress Anxiety. 2019;36(9):887-94. [Link] [DOI:10.1002/da.22934] [PMID]
71. Li L, Reinhardt JD, Van Dyke C, Wang H, Liu M, Yamamoto A, et al. Prevalence and risk factors of post-traumatic stress disorder among elderly survivors six months after the 2008 Wenchuan earthquake in China. BMC Psychiatry. 2020;20:78. [Link] [DOI:10.1186/s12888-020-2474-z] [PMID] [PMCID]
72. Morgan CA, Rasmusson AM, Winters B, Hauger RL, Morgan J, Hazlett G, et al. Trauma exposure rather than posttraumatic stress disorder is associated with reduced baseline plasma neuropeptide-Y levels. Biol Psychiatry. 2003;54(10):1087-91. [Link] [DOI:10.1016/S0006-3223(03)00433-5]
73. Rasmusson AM, Hauger RL, Morgan CA, Bremner JD, Charney DS, Southwick SM. Low baseline and yohimbine-stimulated plasma neuropeptide Y (NPY) levels in combat-related PTSD. Biol Psychiatry. 2000;47(6):526-39. [Link] [DOI:10.1016/S0006-3223(99)00185-7]
74. Serova LI, Nwokafor C, Van Bockstaele EJ, Reyes BAS, Lin X, Sabban EL. Single prolonged stress PTSD model triggers progressive severity of anxiety, altered gene expression in locus coeruleus and hypothalamus and effected sensitivity to NPY. Eur Neuropsychopharmacol. 2019;29(4):482-92. [Link] [DOI:10.1016/j.euroneuro.2019.02.010] [PMID]
75. Nwokafor C, Serova LI, Nahvi RJ, McCloskey J, Sabban EL. Activation of NPY receptor subtype 1 by [D-His26] NPY is sufficient to prevent development of anxiety and depressive like effects in the single prolonged stress rodent model of PTSD. Neuropeptides. 2020;80:102001. [Link] [DOI:10.1016/j.npep.2019.102001] [PMID]
76. Meyer RM, Burgos-Robles A, Liu E, Correia SS, Goosens KA. A ghrelin-growth hormone axis drives stress-induced vulnerability to enhanced fear. Mol Psychiatry. 2014;19(12):1284-94. [Link] [DOI:10.1038/mp.2013.135] [PMID] [PMCID]
77. Rao MN, Chau A, Madden E, Inslicht S, Talbot L, Richards A, et al. Hyperinsulinemic response to oral glucose challenge in individuals with posttraumatic stress disorder. Psychoneuroendocrinology. 2014;49:171-81. [Link] [DOI:10.1016/j.psyneuen.2014.07.006] [PMID] [PMCID]
78. Hill MN, Bierer LM, Makotkine I, Golier JA, Galea S, McEwen BS, et al. Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the world trade center attacks. Psychoneuroendocrinology. 2013;38(12):2952-61. [Link] [DOI:10.1016/j.psyneuen.2013.08.004] [PMID] [PMCID]
79. Neumeister A, Normandin MD, Pietrzak RH, Piomelli D, Zheng MQ, Gujarro-Anton A, et al. Elevated brain cannabinoid CB 1 receptor availability in post-traumatic stress disorder: A positron emission tomography study. Mol Psychiatry. 2013;18(9):1034-40. [Link] [DOI:10.1038/mp.2013.61] [PMID] [PMCID]
80. Sondergaard HP, Hansson LO, Theorell T. Elevated blood levels of dehydroepiandrosterone sulfate vary with symptom load in posttraumatic stress disorder: Findings from a longitudinal study of refugees in Sweden. Psychother Psychosom. 2002;71(5):298-303. [Link] [DOI:10.1159/000064806] [PMID]
81. Spivak B, Maayan R, Kotler M, Mester R, Gil-Ad I, Shtaif B, et al. Elevated circulatory level of GABA A-antagonistic neurosteroids in patients with combat-related post-traumatic stress disorder. Psychol Med. 2000;30(5):1227-31. [Link] [DOI:10.1017/S0033291799002731] [PMID]
82. Yehuda R, Brand SR, Golier JA, Yang RK. Clinical correlates of DHEA associated with post‐traumatic stress disorder. Acta Psychiatr Scand. 2006;114(3):187-93. [Link] [DOI:10.1111/j.1600-0447.2006.00801.x] [PMID]
83. Morgan CA, Southwick S, Hazlett G, Rasmusson A, Hoyt G, Zimolo Z, et al. Relationships among plasma dehydroepiandrosterone sulfate and cortisol levels, symptoms of dissociation, and objective performance in humans exposed acute stress. Arch Gen Psychiatry. 2004;61(8):819-25. [Link] [DOI:10.1001/archpsyc.61.8.819] [PMID]
84. De Kloet CS, Vermetten E, Geuze E, Wiegant VM, Westenberg HGM. Elevated plasma arginine vasopressin levels in veterans with posttraumatic stress disorder. J Psychiatr Res. 2008;42(3):192-8. [Link] [DOI:10.1016/j.jpsychires.2006.11.009] [PMID]
85. Stappenbeck CA, Hellmuth JC, Simpson T, Jakupcak M. The effects of alcohol problems, PTSD, and combat exposure on nonphysical and physical aggression among Iraq and Afghanistan war veterans. Psychol Trauma. 2014;6(1):65-72. [Link] [DOI:10.1037/a0031468] [PMID] [PMCID]
86. Boscarino JA. Posttraumatic stress disorder and physical illness: Results from clinical and epidemiologic studies. Ann NY Acad Sci. 2004;1032:141-53. [Link] [DOI:10.1196/annals.1314.011] [PMID]
87. Boscarino JA, Chang J. Electrocardiogram abnormalities among men with stress-related psychiatric disorders: Implications for coronary heart disease and clinical research. Ann Behav Med. 1999;21(3):227-34. [Link] [DOI:10.1007/BF02884839] [PMID]
88. Weiss T, Skelton K, Phifer J, Jovanovic T, Gillespie CF, Smith A, et al. Posttraumatic stress disorder is a risk factor for metabolic syndrome in an impoverished urban population. Gen Hosp Psychiatry. 2011;33(2):135-42. [Link] [DOI:10.1016/j.genhosppsych.2011.01.002] [PMID] [PMCID]
89. Maes M, Lin Ah, Delmeire L, Van Gastel A, Kenis G, De Jongh R, et al. Elevated serum interleukin-6 (IL-6) and IL-6 receptor concentrations in posttraumatic stress disorder following accidental man-made traumatic events. Biol Psychiatry. 1999;45(7):833-9. [Link] [DOI:10.1016/S0006-3223(98)00131-0]
90. Spivak B, Shohat B, Mester R, Avraham S, Gil-Ad I, Bleich A, et al. Elevated levels of serum interleukin-1β in combat-related posttraumatic stress disorder. Biol Psychiatry. 1997;42(5):345-8. [Link] [DOI:10.1016/S0006-3223(96)00375-7]
91. Smith AK, Conneely KN, Kilaru V, Mercer KB, Weiss TE, Bradley B, et al. Differential immune system DNA methylation and cytokine regulation in post‐traumatic stress disorder. Am J Med Genet B Neuropsychiatr Genet. 2011;156(6):700-8. [Link] [DOI:10.1002/ajmg.b.31212] [PMID] [PMCID]
92. Wang W, Wang L, Xu H, Cao C, Liu P, Luo S, et al. Characteristics of pro-and anti-inflammatory cytokines alteration in PTSD patients exposed to a deadly earthquake. J Affect Disord. 2019;248:52-8. [Link] [DOI:10.1016/j.jad.2019.01.029] [PMID]
93. Hori H, Yoshida F, Itoh M, Lin M, Niwa M, Ino K, et al. Proinflammatory status-stratified blood transcriptome profiling of civilian women with PTSD. Psychoneuroendocrinology. 2020;111:104491. [Link] [DOI:10.1016/j.psyneuen.2019.104491] [PMID]
94. Miller RJ, Sutherland AG, Hutchison JD, Alexander DA. C-reactive protein and interleukin 6 receptor in post-traumatic stress disorder: A pilot study. Cytokine. 2001;13(4):253-5. [Link] [DOI:10.1006/cyto.2000.0825] [PMID]
95. Plantinga L, Bremner JD, Miller AH, Jones DP, Veledar E, Goldberg J, et al. Association between posttraumatic stress disorder and inflammation: A twin study. Brain Behav Immun. 2013;30:125-32. [Link] [DOI:10.1016/j.bbi.2013.01.081] [PMID] [PMCID]
96. Rohleder N, Wolf JM, Wolf OT. Glucocorticoid sensitivity of cognitive and inflammatory processes in depression and posttraumatic stress disorder. Neurosci Biobehav Rev. 2010;35(1):104-14. [Link] [DOI:10.1016/j.neubiorev.2009.12.003] [PMID]
97. Rohleder N, Joksimovic L, Wolf JM, Kirschbaum C. Hypocortisolism and increased glucocorticoid sensitivity of pro-Inflammatory cytokine production in Bosnian war refugees with posttraumatic stress disorder. Biol Psychiatry. 2004;55(7):745-51. [Link] [DOI:10.1016/j.biopsych.2003.11.018] [PMID]
98. Liang Y, Zhou Y, Shen P. NF-kappaB and its regulation on the immune system. Cell Mol Immunol. 2004;1(5):343-50. [Link]
99. Bierhaus A, Wolf J, Andrassy M, Rohleder N, Humpert PM, Petrov D, et al. A mechanism converting psychosocial stress into mononuclear cell activation. Proc Natl Acad Sci USA. 2003;100(4):1920-5. [Link] [DOI:10.1073/pnas.0438019100] [PMID] [PMCID]
100. O'Donovan A, Sun B, Cole S, Rempel H, Lenoci M, Pulliam L, et al. Transcriptional control of monocyte gene expression in post-traumatic stress disorder. Dis Markers. 2011;30(2-3):123-32. [Link] [DOI:10.1155/2011/560572] [PMID] [PMCID]
101. Raison CL, Capuron L, Miller AH. Cytokines sing the blues: Inflammation and the pathogenesis of depression. Trends Immunol. 2006;27(1):24-31. [Link] [DOI:10.1016/j.it.2005.11.006] [PMID] [PMCID]
102. Boscarino JA. Diseases among men 20 years after exposure to severe stress: Implications for clinical research and medical care. Psychosom Med. 1997;59(6):605-14. [Link] [DOI:10.1097/00006842-199711000-00008] [PMID]
103. Klein SL. Hormones and mating system affect sex and species differences in immune function among vertebrates. Behav Process. 2000;51(1-3):149-66. [Link] [DOI:10.1016/S0376-6357(00)00125-X]
104. Eraly SA, Nievergelt CM, Maihofer AX, Barkauskas DA, Biswas N, Agorastos A, et al. Assessment of plasma C-reactive protein as a biomarker of posttraumatic stress disorder risk. JAMA Psychiatry. 2014;71(4):423-31. [Link] [DOI:10.1001/jamapsychiatry.2013.4374] [PMID] [PMCID]
105. Liu L, Wang L, Cao C, Cao X, Zhu Y, Liu P, et al. Serotonin transporter 5-HTTLPR genotype is associated with intrusion and avoidance symptoms of DSM-5 posttraumatic stress disorder (PTSD) in Chinese earthquake survivors. Anxiety Stress Coping. 2018;31(3):318-27. [Link] [DOI:10.1080/10615806.2017.1420174] [PMID]
106. Skelton K, Ressler KJ, Norrholm SD, Jovanovic T, Bradley-Davino B. PTSD and gene variants: New pathways and new thinking. Neuropharmacology. 2012;62(2):628-37. [Link] [DOI:10.1016/j.neuropharm.2011.02.013] [PMID] [PMCID]
107. Hossack MR, Reid MW, Aden JK, Gibbons T, Noe JC, Willis AM. Adverse Childhood Experience, Genes, and PTSD Risk in Soldiers: A Methylation Study. Mil Med. 2020;185(3-4):377-84. [Link] [DOI:10.1093/milmed/usz292] [PMID]
108. Uka AG, Agani F, Blyta A, Hoxha B, Haxhibeqiri S, Haxhibeqiri V, et al. Role of the allelic variation in the 5-hydroxytryptamine receptor 1A (HTR1A) and the tryptophan hydroxylase 2 (TPH2) genes in the development of PTSD. Psychiatr Danub. 2019;31(2):256-62. [Link] [DOI:10.24869/psyd.2019.256] [PMID]
109. Buckley B, Nugent N, Sledjeski E, Raimonde AJ, Spoonster E, Bogart LM, et al. Evaluation of initial posttrauma cardiovascular levels in association with acute PTSD symptoms following a serious motor vehicle accident. J Trauma Stress. 2004 Aug;17(4):317-24. [Link] [DOI:10.1023/B:JOTS.0000038480.87290.4a] [PMID]
110. Blanchard EB, Hickling EJ, Galovski T, Veazey C. Emergency room vital signs and PTSD in a treatment seeking sample of motor vehicle accident survivors. J Trauma Stress. 2002;15(3):199-204. [Link] [DOI:10.1023/A:1015299126858] [PMID]
111. Shalev AY, Sahar T, Freedman S, Peri T, Glick N, Brandes D, et al. A prospective study of heart rate response following trauma and the subsequent development of posttraumatic stress disorder. Arch Gen Psychiatry. 1998;55(6):553-9. [Link] [DOI:10.1001/archpsyc.55.6.553] [PMID]
112. Orr SP, Metzger LJ, Lasko NB, Macklin ML, Hu FB, Shalev AY, et al. Physiologic responses to sudden, loud tones in monozygotic twins discordant for combat exposure: Association with posttraumatic stress disorder. Arch Gen Psychiatry. 2003;60(3):283-8. [Link] [DOI:10.1001/archpsyc.60.3.283] [PMID]
113. Shalev AY, Peri T, Brandes D, Freedman S, Orr SP, Pitman RK. Auditory startle response in trauma survivors with posttraumatic stress disorder: A prospective study. Am J Psychiatry. 2000;157(2):255-61. [Link] [DOI:10.1176/appi.ajp.157.2.255] [PMID]
114. Keane TM, Wilson JP. Assessing psychological trauma and PTSD. New York: Guilford Publications; 2004. [Link]
115. Griffin MG. A prospective assessment of auditory startle alterations in rape and physical assault survivors. J Trauma Stress. 2008;21(1):91-9. [Link] [DOI:10.1002/jts.20300] [PMID]
116. Orr SP, Roth WT. Psychophysiological assessment: Clinical applications for PTSD. J Affect Disord. 2000;61(3):225-40. [Link] [DOI:10.1016/S0165-0327(00)00340-2]
117. Pole N, Neylan TC, Best SR, Orr SP, Marmar CR. Fear‐potentiated startle and posttraumatic stress symptoms in urban police officers. J Trauma Stress. 2003;16(5):471-9. [Link] [DOI:10.1023/A:1025758411370] [PMID]
118. Orr SP, Lasko NB, Macklin ML, Pineles SL, Chang Y, Pitman RK. Predicting post-trauma stress symptoms from pre-trauma psychophysiologic reactivity, personality traits and measures of psychopathology. Biol Mood Anxiety Disord. 2012;2:8. [Link] [DOI:10.1186/2045-5380-2-8] [PMID] [PMCID]
119. Neylan TC, Otte C, Yehuda R, Marmar CR. Neuroendocrine regulation of sleep disturbances in PTSD. Ann NY Acad Sci. 2006;1071:203-15. [Link] [DOI:10.1196/annals.1364.015] [PMID]
120. Kobayashi I, Boarts JM, Delahanty DL. Polysomnographically measured sleep abnormalities in PTSD: A meta‐analytic review. Psychophysiology. 2007;44(4):660-9. [Link] [DOI:10.1111/j.1469-8986.2007.537.x] [PMID]
121. Pitman RK, Orr SP, Forgue DF, De Jong JB, Claiborn JM. Psychophysiologic assessment of posttraumatic stress disorder imagery in Vietnam combat veterans. Arch Gen Psychiatry. 1987;44(11):970-5. [Link] [DOI:10.1001/archpsyc.1987.01800230050009] [PMID]
122. Lang PJ, Levin DN, Miller GA, Kozak MJ. Fear behavior, fear imagery, and the psychophysiology of emotion: The problem of affective response integration. J Abnorm Psychol. 1983;92(3):276-306. [Link] [DOI:10.1037/0021-843X.92.3.276]
123. Pitman RK, Orr SP, Forgue DF, Altman B, De Jong JB, Herz LR. Psychophysiologic responses to combat imagery of Vietnam veterans with posttraumatic stress disorder versus other anxiety disorders. J Abnorm Psychol. 1990;99(1):49-54. [Link] [DOI:10.1037/0021-843X.99.1.49]
124. Orr SP, Pitman RK, Lasko NB, Herz LR. Psychophysiological assessment of posttraumatic stress disorder imagery in world war II and Korean combat veterans. J Abnorm Psychol. 1993;102(1):152-9. [Link] [DOI:10.1037/0021-843X.102.1.152]
125. Shalev AY, Orr SP, Pitman RK. Psychophysiologic response during script-driven imagery as an outcome measure in posttraumatic stress disorder. J Clin Psychiatry. 1992;53(9):324-6. [Link]
126. McTeague LM, Lang PJ, Laplante MC, Cuthbert BN, Shumen JR, Bradley MM. Aversive imagery in posttraumatic stress disorder: trauma recurrence, comorbidity, and physiological reactivity. Biol Psychiatry. 2010;67(4):346-56. [Link] [DOI:10.1016/j.biopsych.2009.08.023] [PMID] [PMCID]
127. Keane TM, Kolb LC, Kaloupek DG, Orr SP, Blanchard EB, Thomas RG, et al. Utility of psychophysiology measurement in the diagnosis of posttraumatic stress disorder: Results from a department of Veteran's Affairs cooperative study. J Consult Clin Psychol. 1998;66(6):914-23. [Link] [DOI:10.1037/0022-006X.66.6.914]
128. American psychiatric association. Diagnostic and statistical manual of mental disorders (DSM-5®). Washington: American Psychiatric Publishing; 2013. [Link] [DOI:10.1176/appi.books.9780890425596]
129. Marx BP, Bovin MJ, Suvak MK, Monson CM, Sloan DM, Fredman SJ, et al. Concordance between physiological arousal and subjective distress among Vietnam combat veterans undergoing challenge testing for PTSD. J Trauma Stress. 2012;25(4):416-25. [Link] [DOI:10.1002/jts.21729] [PMID]
130. Rothbaum BO, Price M, Jovanovic T, Norrholm SD, Gerardi M, Dunlop B, et al. A randomized, double-blind evaluation of D-cycloserine or alprazolam combined with virtual reality exposure therapy for posttraumatic stress disorder in Iraq and Afghanistan war veterans. Am J Psychiatry. 2014;171(6):640-8. [Link] [DOI:10.1176/appi.ajp.2014.13121625] [PMID] [PMCID]
131. Amstadter AB, Nugent NR, Koenen KC. Genetics of PTSD: Fear conditioning as a model for future research. Psychiatr Ann. 2009;39(6):358-67. [Link] [DOI:10.3928/00485713-20090526-01] [PMID] [PMCID]
132. Foa EB, Steketee G, Rothbaum BO. Behavioral/cognitive conceptualizations of post-traumatic stress disorder. Behav Ther. 1989;20(2):155-76. [Link] [DOI:10.1016/S0005-7894(89)80067-X]
133. Jovanovic T, Ressler KJ. How the neurocircuitry and genetics of fear inhibition may inform our understanding of PTSD. Am J Psychiatry. 2010;167(6):648-62. [Link] [DOI:10.1176/appi.ajp.2009.09071074] [PMID] [PMCID]
134. Orr SP, Metzger LJ, Lasko NB, Macklin ML, Peri T, Pitman RK. De novo conditioning in trauma-exposed individuals with and without posttraumatic stress disorder. J Abnorm Psychol. 2000;109(2):290-8. [Link] [DOI:10.1037/0021-843X.109.2.290]
135. Jovanovic T, Ely T, Fani N, Glover EM, Gutman D, Tone EB, et al. Reduced neural activation during an inhibition task is associated with impaired fear inhibition in a traumatized civilian sample. Cortex. 2013;49(7):1884-91. [Link] [DOI:10.1016/j.cortex.2012.08.011] [PMID] [PMCID]
136. Hughes KC, Shin LM. Functional neuroimaging studies of post-traumatic stress disorder. Expert Rev Neurother. 2011;11(2):275-85. [Link] [DOI:10.1586/ern.10.198] [PMID] [PMCID]
137. Protopopescu X, Pan H, Tuescher O, Cloitre M, Goldstein M, Engelien W, et al. Differential time courses and specificity of amygdala activity in posttraumatic stress disorder subjects and normal control subjects. Biol Psychiatry. 2005;57(5):464-73. [Link] [DOI:10.1016/j.biopsych.2004.12.026] [PMID]
138. Rauch SL, Whalen PJ, Shin LM, McInerney SC, Macklin ML, Lasko NB, et al. Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: A functional MRI study. Biol Psychiatry. 2000;47(9):769-76. [Link] [DOI:10.1016/S0006-3223(00)00828-3]
139. Corbo V, Clement MH, Armony JL, Pruessner JC, Brunet A. Size versus shape differences: Contrasting voxel-based and volumetric analyses of the anterior cingulate cortex in individuals with acute posttraumatic stress disorder. Biol Psychiatry. 2005;58(2):119-24. [Link] [DOI:10.1016/j.biopsych.2005.02.032] [PMID]
140. Johnson J, Raab M, Heekeren HR, Johnson J. Mind and motion: the bidirectional link between thought and action. Amsterdam: Elsevier; 2009. [Link]
141. Gilbertson MW, Shenton ME, Ciszewski A, Kasai K, Lasko NB, Orr SP, et al. Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma. Nat Neurosci. 2002;5(11):1242-7. [Link] [DOI:10.1038/nn958] [PMID] [PMCID]
142. Admon R, Milad MR, Hendler T. A causal model of post-traumatic stress disorder: Disentangling predisposed from acquired neural abnormalities. Trends Cogn Sci. 2013;17(7):337-47. [Link] [DOI:10.1016/j.tics.2013.05.005] [PMID]
143. Neylan TC, Mueller SG, Wang Z, Metzler TJ, Lenoci M, Truran D, et al. Insomnia severity is associated with a decreased volume of the CA3/dentate gyrus hippocampal subfield. Biol Psychiatry. 2010;68(5):494-6. [Link] [DOI:10.1016/j.biopsych.2010.04.035] [PMID] [PMCID]
144. Neylan TC, Schadt EE, Yehuda R. Biomarkers for combat-related PTSD: Focus on molecular networks from high-dimensional data. Eur J Psychotraumatol. 2014;5:23938. [Link] [DOI:10.3402/ejpt.v5.23938] [PMID] [PMCID]
145. Lehrner A, Yehuda R. Biomarkers of PTSD: Military applications and considerations. Eur J Psychotraumatol. 2014;5. [Link] [DOI:10.3402/ejpt.v5.23797]
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Eftekhari A, Bakhtiari M. Biomarkers, a Diagnostic Tool for Post-Traumatic Stress Disorder; Promising Horizons in Neuroscience Research. Iran J Forensic Med 2020; 26 (3) :199-209
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Volume 26, Issue 3 (2020) Back to browse issues page
مجله پزشکی قانونی ایران Iranian Journal of Forensic Medicine
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