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:: Volume 26, Issue 4 (2020) ::
Sci J Forensic Med 2020, 26(4): 199-209 Back to browse issues page
Biomarkers, a Diagnostic Tool for Post-Traumatic Stress Disorder; Promising Horizons in Neuroscience Research
A. Eftekhari1, M. Bakhtiari *2
1- Department of Clinical Psychology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Department of Clinical Psychology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran , Maryam_bakhtiyari@sbmu.ac.ir
Abstract:   (256 Views)
Introduction: Post-traumatic stress disorder (PTSD) is a heterogeneous disorder that affects people at risk for trauma. Although its diagnostic features have been reclassified in the Diagnostic and Statistical Manual of Mental Disorders, Version 5 (DSM-5), the disorder is characterized by excessive and unwanted trauma reminders as well as the avoidance of trauma reminders. Cognitive patterns and negative moods of this heterogeneity indicate multiple neurological mechanisms in the context of PTSD. Research over the past few decades has shown several potential ways to identify diagnostic biomarkers for PTSD. These include monoadrenergic transmission systems, the hypothalamic-pituitary-adrenal axis (HPA), metabolic, hormonal pathways, inflammatory mechanisms, psychophysiological reactions, and cerebral neural circuits. The present study presents the research literature concerning the most promising biomarkers in diagnosing PTSD with special emphasis on the interaction between neurological effects on disease risk and progression of symptoms. Such biomarkers are likely to be identified by multidimensional models derived from comprehensive descriptions of molecular, neurological, behavioral, and clinical phenotypes.
Conclusion: Post-traumatic stress disorder biomarkers can provide promising horizons for early diagnosis and treatment of the disorder and provide clinicians with tools to make more accurate diagnoses of the disorder. Also, the existing research literature in this field can serve the biological contexts related to PTSD symptoms and future studies' goals.
Keywords: |Neuroscience research|biomarkers|diagnostic tools|post-traumatic stress disorder. ,
Full-Text [PDF 458 kb]   (67 Downloads)    
Article Type: Analytical Review | Subject: Forensic Neurology
Received: 2020/11/22 | Accepted: 2021/03/1 | Published: 2021/03/7
* Corresponding Author Address: Department of Clinical Psychology, Faculty of Medicine, Shahid Beheshti University, Tehran, Iran. Postal code: 1985717443
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Eftekhari A, Bakhtiari M. Biomarkers, a Diagnostic Tool for Post-Traumatic Stress Disorder; Promising Horizons in Neuroscience Research. Sci J Forensic Med. 2020; 26 (4) :199-209
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Volume 26, Issue 4 (2020) Back to browse issues page
مجله پزشکی قانونی Scientific Journal of Forensic Medicine
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