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Estimation of efficiency of blood group in comparison with DNA typing tests in disputed paternity
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Ali Reza Sabouri   1, Hamideh Yadegari |
| 1- , Isfahan@LMO.org.ir |
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Abstract: (19231 Views) |
| Abstract
Back ground & Aim: Blood grouping test is a tool to resolve the problems of disputed paternity. Therefore, we
decided to calculate its chance of exclusion depending on the phenotype data on seven blood groups (ABO, Rh, MNSs,
kell, kidd, Lutheran and P1
) in south and central parts of Iran. Moreover, red cells tests and full STRs results for paternity disputes were compared. The main aim of this research is to evaluate the efficiency of blood grouping test in
comparison with DNA typing.
Materials & method: Blood Samples were obtained from 174 unrelated individuals belonging to the south and
central parts of Iran. Then, DNA Typing for the 12 Loci and blood testing were performed simultaneously.
Findings: The chance of exclusion in each system of ABH, Rh, MNSs, kell, kidd, Lutheran and P1 is 19.5%,
29.77%, 22.28%, 3.64%, 9.77%, 3.47% and 4.5%, respectively. From 82 paternity tested, in 42 cases no mismatch
was observed for STRs that supported paternity. In 40 cases that alleged father was excluded by DNA Typing, in 22
(55%) cases, there are no mismatches in blood groups. 18 (45%) cases showed mismatches at one or more antigenic
systems. Overall, two alleged farther were excluded just by red cell typing regarding to criteria of non-paternity
remaining cases needed DNA Typing.
Conclusion: This study shawed that considering the probability of excluding of all mentioned blood groups
systems, 64.83% of them can not be used to prove paterninty. On the other hand, owing to low efficiency in exclusion,
high cost, laboratory error rate and availability of DNA Typing, we recommended that routine red cell tests for court
cases should be limited to AB and Rh [CcDEe] systems. |
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| Keywords: Blood groups, paternity, DNA Typing |
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Full-Text [PDF 638 kb]
(2019 Downloads)
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Type of Article: Research Article |
Subject:
Forensic Medicine
Received: 2008/08/30 | Accepted: 2018/03/29 | ePublished: 2018/03/29
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