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Survey on the Protective Effect of Total Hydro-alcoholic Extract of Artemisia Aucheri on Mercuric Chloride-induced Nephrotoxicity in Male Mice
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Elham Hakimizadeh1   , Hanieh Baniasadi Pour1 , Hossein Rezazadeh1 , Ali Ansari Jaberi1 , Narges Mashayekhi1 , Marzieh Ismaili1 , Reza Nejad Hassan1 , Fatemeh Amin1 , Ali Shamsizadeh1 , Fatemeh Ayoobi1 , Lida Zare1 , Mohammad Allah Tavakoli 2 |
1- Rafsanjan University of Medical Sciences
2- Rafsanjan University of Medical Sciences , m_alahtavakoli@rums.ac.ir |
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Abstract: (17966 Views) |
| Background: Heavy metals cause to nephrotoxicity in kidney tissue of human and animals through increased production of oxygen free radicals. Plants Antioxidants are of good choices for protection against the toxicity of these compounds. In the current study, the protective effect of hydro alcoholic extract of Artemisia was assessed on Mercuric chloride-induced nephrotoxicity.
Methods: In this study 28 male mice were used. Animals were randomly divided into 4 groups (N=7) as: 1 - Control, 2 - Mercuric chloride, 3 - Mercuric chloride with extract of Artemisia and 4 – Extract of Artemisia groups. Mercuric chloride and Artemisia extracts intra-peritoneal were injected with the dose of 1.5 mg/kg and 200 mg/kg for 8 days, respectively. Then, blood samples were prepared and nephrotoxicity was determined by measuring serum urea and creatinine, using spectrophotometry (device SINCO) and specific kit (Pars test). Data were reported as Mean ± SEM via SPSS software. One-way ANOVA followed by Tukey test was used for data analysis and P <0.05 was considered as a significant difference.
Findings: Compared to the Mercuric chloride group, Artemisia extract caused a significant decrease in serum urea and creatinine in the combined Artemisia extract with Mercuric chloride group. Mercuric chloride also caused a significant increase in serum urea and creatinine in the Mercuric chloride group compared to the control group.
Conclusion: Our results showed that the extract of Artemisia has protective effects against nephrotoxicity induced by heavy metals such as mercury. |
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| Keywords: Artemisia, Nephrotoxicity, Mercury Chloride |
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Full-Text [PDF 430 kb]
(2966 Downloads)
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Type of Article: Research Article |
Received: 2014/02/16 | Revised: 2014/02/16 | Accepted: 2014/02/16 | ePublished: 2014/02/16
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