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:: Volume 19, Issue 2 And 3 (2013) ::
Sci J Forensic Med 2013, 19(2 And 3): 251-256 Back to browse issues page
Survey on the Protective Effect of Total Hydro-alcoholic Extract of Artemisia Aucheri on Mercuric Chloride-induced Nephrotoxicity in Male Mice
Elham Hakimizadeh1, Hanieh Baniasadi Pour2, Hossein Rezazadeh1, Ali Ansari Jaberi1, Narges Mashayekhi2, Marzieh Ismaili2, Reza Nejad Hassan2, Fatemeh Amin1, Ali Shamsizadeh1, Fatemeh Ayoobi1, Lida Zare1, Mohammad Allah Tavakoli *3
1- Rafsanjan University of Medical Sciences, Pharmacology-Physiology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
2- Rafsanjan University of Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
3- Rafsanjan University of Medical Sciences , m_alahtavakoli@rums.ac.ir
Abstract:   (16182 Views)
Background: Heavy metals cause to nephrotoxicity in kidney tissue of human and animals through increased production of oxygen free radicals. Plants Antioxidants are of good choices for protection against the toxicity of these compounds. In the current study, the protective effect of hydro alcoholic extract of Artemisia was assessed on Mercuric chloride-induced nephrotoxicity. Methods: In this study 28 male mice were used. Animals were randomly divided into 4 groups (N=7) as: 1 - Control, 2 - Mercuric chloride, 3 - Mercuric chloride with extract of Artemisia and 4 – Extract of Artemisia groups. Mercuric chloride and Artemisia extracts intra-peritoneal were injected with the dose of 1.5 mg/kg and 200 mg/kg for 8 days, respectively. Then, blood samples were prepared and nephrotoxicity was determined by measuring serum urea and creatinine, using spectrophotometry (device SINCO) and specific kit (Pars test). Data were reported as Mean ± SEM via SPSS software. One-way ANOVA followed by Tukey test was used for data analysis and P <0.05 was considered as a significant difference. Findings: Compared to the Mercuric chloride group, Artemisia extract caused a significant decrease in serum urea and creatinine in the combined Artemisia extract with Mercuric chloride group. Mercuric chloride also caused a significant increase in serum urea and creatinine in the Mercuric chloride group compared to the control group. Conclusion: Our results showed that the extract of Artemisia has protective effects against nephrotoxicity induced by heavy metals such as mercury.
Keywords: Artemisia, Nephrotoxicity, Mercury Chloride
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Article Type: Original Research |
* Corresponding Author Address: Pharmacology-Physiology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
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Hakimizadeh E, Baniasadi Pour H, Rezazadeh H, Ansari Jaberi A, Mashayekhi N, Ismaili M, et al . Survey on the Protective Effect of Total Hydro-alcoholic Extract of Artemisia Aucheri on Mercuric Chloride-induced Nephrotoxicity in Male Mice. Sci J Forensic Med. 2013; 19 (2 and 3) :251-256
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Volume 19, Issue 2 And 3 (2013) Back to browse issues page
مجله پزشکی قانونی Scientific Journal of Forensic Medicine
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